antihypertensive drugs Part 1
antihypertensive drugs The preceding equation is a familiar one from physiology. According to this equation, a decrease in either cardiac output or peripheral resistance will decrease blood pressure. Conversely, if high blood pressure is present, something must have increased one of the two variables.
antihypertensive drugs Part 2
Several factors will increase cardiac output, including increased heart rate, increased contractility, and increased sodium and water retention. Vasoconstriction will increase peripheral resistance. Decreasing one or more of these factors is the goal of antihypertensive therapy.
antihypertensive drugs Part 3
Diuretics can be used to decrease blood volume. Drugs are available that interfere with the renin-angiotensin system, which is intimately involved in salt and water balance in the body. Finally, drugs can be used to decrease peripheral vascular resistance or cardiac output. This can be done with direct-acting vasodilators or by using agents that block sympathetic nervous system output.
Other Antihypertensive Agents: