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CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS

CONTRAINDICATIONS ,WARNINGS AND PRECAUTIONS

CONTRAINDICATIONS

NORVASC is contraindicated in patients with known sensitivity to amlodipine.

WARNINGS AND PRECAUTIONS



1 Hypotension

Symptomatic hypotension is possible, particularly in patients with severe aortic stenosis. Because of the gradual onset of action, acute hypotension is unlikely.

      2 Increased Angina or Myocardial Infarction

Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of NORVASC, particularly in patients with severe obstructive coronary artery disease.



      3 Patients with Hepatic Failure

Because NORVASC is extensively metabolized by the liver and the plasma elimination half-life (t 1/2) is 56 hours in patients with impaired hepatic function, titrate slowly when administering NORVASC to patients with severe hepatic impairment.