1 Impact of Other Drugs on Amlodipine
Co-administration of drug interaction with CYP3A inhibitors (moderate and strong) results in increased systemic exposure to amlodipine and may require dose reduction. Monitor for symptoms of hypotension and edema when amlodipine is co-administered with CYP3A inhibitors to determine the need for dose adjustment.
Monitor for hypotension when sildenafil is co-administered with amlodipine
2 Impact of Amlodipine on Other Drugs
Simvastatin of DRUG INTERACTIONS
Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when co-administered. Frequent monitoring of trough blood levels of cyclosporine and tacrolimus is recommended and adjust the dose when appropriate the DRUG INTERACTIONS